Phyt-N-Resist®, the first pure phytoene for skincare

Phytoene is a colorless carotenoid produced through natural sugars fermentation by Deinococcus geothermalis, an extremophile bacterium.

Created by DEINOVE and consisting of phytoene concentrated in a refined jojoba oil, Phyt-N-Resist® helps fight against skin aging by reducing oxidative stress and accelerating skin repair.

Its efficacy and tolerability have been successfully demonstrated by in vitro, ex vivo and clinical studies.

Different skin care formulations have been developed, demonstrating ease of formulating and good stability. Thanks to its stability at high temperature, it could also be considered for make-up applications.

Deinove featured this new active ingredient at In-cosmetics Global event (Amsterdam, April 17-19).


A breakthrough in naturally-sourced active ingredients: Deinove bioproduced the 1st pure Phytoene

Nature is a prodigious laboratory, capable of designing highly efficient molecules.

Both skin cells and plants rely on a common substance to protect themselves from oxidative stress: Phytoene, the original precursor of all carotenoids.  However, unlike plants, skin cannot synthesize it. Phytoene counts among these essential molecules that need to be brought through external supplementation.

So far there was no way to extract pure Phytoene. None of the available production processes from plants allows the production of pure Phytoene. They provide only a mix of carotenoids, at low concentration, and with varying degrees of stability and colors.  

Tapping into the extraordinary resources of biomimetism and symbiosis, harnessing the potential of Deinococcus geothermalis, a UV-resistant extremophile bacterium, Deinove has for the first time ever achieved the bioproduction of pure Phytoene.

Phyt-N-Resist®: Extended anti-ageing properties

Carotenoids are known for their anti-oxidant properties. Phyt-N-Resist® has been successfully tested for its ability to reduce the amount of lipoperoxidation products, appearing after cells exposure to UV radiations. Indeed, phytoene accumulates in cellular membranes to prevent cellular degradation. By protecting membranes lipids from free radicals and peroxidation, Phyt-N-Resist® reduces the harmful effects of oxidation and, ultimately, skin aging.

But Deinove went even further. The company has put in place a systematic screening of its active ingredients across several dimensions. This comprehensive, innovative approach has highlighted a previously untapped feature under the carotenoid family: cell renewal stimulation. Wounded skin is able to regenerate under the action of phytoene.

These properties were subsequently confirmed by a conclusive clinical study, demonstrating its beneficial effect on skin firmness, elasticity and radiance. Above all, Phyt-N-Resist® has a significant anti-wrinkles action.

This makes Phyt-N-Resist® a thorough anti-aging active ingredient for the beauty industry.

Key product features

INCI: Simmondsia chinensis (Jojoba) seed oil and C30-45 Olefin

China Compliant

High-performance anti-aging active molecule

  • Sharper approach to cell anti-oxidant protection
  • Clinically tested skin regeneration


  • Colorless & stable carotenoid
  • Consistent process and product quality
  • A concentrated ingredient, low incorporation rate
  • Easy to formulate

Rich narrative material

  • Advanced biotech science
  • Exclusive patented innovation
  • Ancient and highly resilient micro-organism surviving in extreme environments
  • Biomimetic solution
  • Supplementation of skin natural defenses
  • Made in France


> For more information and to download the product presentation, please follow this link